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Version: 17.06d (Release date: 2017-06-26)
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Tositumomab and Iodine I 131 Tositumomab (Code C72672)

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Terms & Properties

Preferred Name: Tositumomab and Iodine I 131 Tositumomab

Definition: A murine IgG2a lambda monoclonal antibody, both unradiolabeled and radiolabeled with iodine I 131, directed against the human B cell-specific surface antigen CD20. Tositumomab binds to CD20, resulting in complement-dependent cytotoxicity (CDC), antibody-dependent cellular cytotoxicity (ADCC), and apoptosis in B cells expressing CD20; in addition to the antibody-mediated cytotoxicity, iodine I 131 tositumomab delivers cytotoxic ionizing radiation specifically to CD20-expressing B cells. In a two-step therapeutic regimen, a predose of unradiolabeled tositumomab is administered first followed by the administration of a dosimetric dose of iodine I 131 tositumomab; 7-14 days later, a therapeutic dose of iodine I 131 tositumomab is administered. The predose of unradiolabeled tositumomab binds to nontumor B cells, increasing the terminal half-life of radiolabeled antibody while protecting nontumor B cells from radiolabeled antibody-mediated radiocytotoxicity.

NCI-GLOSS Definition: A combination of monoclonal antibodies used to treat certain types of non-Hodgkin lymphoma. The monoclonal antibody tositumomab is given with iodine I 131 tositumomab (a form of tositumomab that has been chemically changed by adding radioactive iodine). Monoclonal antibodies are made in the laboratory and can locate and bind to substances in the body, including cancer cells.

Display Name: Tositumomab and Iodine I 131 Tositumomab

Label: Tositumomab and Iodine I 131 Tositumomab

NCI Thesaurus Code: C72672 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL378645  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bexxar regimen
Bexxar Therapeutic Regimen
Bexxar Therapy
tositumomab
Tositumomab and Iodine I 131 Tositumomab
tositumomab and iodine I 131 tositumomab

External Source Codes: 
PDQ Closed Trial Search ID 588881
PDQ Open Trial Search ID 588881 (check for NCI PDQ open clinical trial info)
NCI META CUI CL378645

Other Properties:
     Name Value (qualifiers indented underneath)
code C72672
Contributing_Source CTRP
Legacy_Concept_Name Tositumomab_I-131_Tositumomab
Semantic_Type Therapeutic or Preventive Procedure

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C72672

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