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Version: 17.06d (Release date: 2017-06-26)
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Pomalidomide (Code C72560)

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Terms & Properties

Preferred Name: Pomalidomide

Definition: An orally bioavailable derivative of thalidomide with potential immunomodulating, antiangiogenic and antineoplastic activities. Although its exact mechanism of action has yet to be fully elucidated, pomalidomide appears to inhibit TNF-alpha production, enhance the activity of T cells and natural killer (NK) cells and enhance antibody-dependent cellular cytotoxicity (ADCC). In addition, pomalidomide may inhibit tumor angiogenesis, promote cell cycle arrest in susceptible tumor cell populations, and stimulate erythropoeisis.

NCI-GLOSS Definition: A substance being studied in the treatment of prostate cancer, multiple myeloma, and other types of cancer. Pomalidomide is a form of the drug thalidomide. It stops the growth of blood vessels, stimulates the immune system, and may kill cancer cells. Pomalidomide is a type of angiogenesis inhibitor and a type of immunomodulatory agent.

Display Name: Pomalidomide

Label: Pomalidomide

NCI Thesaurus Code: C72560 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2347624  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3-Amino-N-(2,6-dioxo-3-piperidyl)phthalimide
4-Amino-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
4-Aminothalidomide
Actimid
CC-4047
Imnovid
Pomalidomide
pomalidomide
POMALIDOMIDE
Pomalyst

External Source Codes: 
CAS Registry Number 19171-19-8 (see NLM ChemIDplus info)
FDA UNII Code D2UX06XLB5
PDQ Closed Trial Search ID 653314
PDQ Open Trial Search ID 653314 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 16085014 (see PubMed Primary Reference info)
UMLS CUI C2347624

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C13H11N3O4
code C72560
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Pomalidomide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C72560

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