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Version: 16.10e (Release date: 2016-10-31)
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Phosphatidylcholine-Bound Silybin (Code C71883)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Phosphatidylcholine-Bound Silybin

Definition: An oral preparation of the flavonoid silybin with potential antioxidant and chemopreventive activities. Silybin, also known as silibinin, is a mixture of two stereoisomers, denoted silybin A and silybin B, and is the major active constituent of silymarin, a mixture of flavonolignans extracted from blessed milk thistle (Silybum marianum). Silybin modulates P-glycoprotein (P-gp)-mediated cellular efflux; has oxygen radical-scavenging effects; inhibits the arachidonic acid pathway; and inhibits various cytochrome P450 enzymes. This agent may also exhibit anti-angiogenic activity, possibly by inducing endothelial cell apoptosis via modulation of the transcription factor NF-kB, the Bcl-2 family of proteins, and caspases. Complexing silybin with phosphatidylcholine increases its bioavailability.

Display Name: Phosphatidylcholine-Bound Silybin

Label: Phosphatidylcholine-Bound Silybin

NCI Thesaurus Code: C71883 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1873062  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Phosphatidylcholine-Bound Silybin
Silybin-Phytosome

External Source Codes: 
PDQ Closed Trial Search ID 558906
PDQ Open Trial Search ID 558906 (check for NCI PDQ open clinical trial info)
UMLS CUI C1873062

Other Properties:
Name Value (qualifiers indented underneath)
code C71883
Contributing_Source CTRP
Legacy_Concept_Name Phosphatidylcholine-Bound_Silybin
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71883

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