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Version: 17.06d (Release date: 2017-06-26)
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hTERT I540/R572Y/D988Y Multipeptide Vaccine (Code C71761)

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Terms & Properties

Preferred Name: hTERT I540/R572Y/D988Y Multipeptide Vaccine

Definition: A peptide vaccine consisting of multiple epitopes derived from the human telomerase reverse transcriptase (hTERT), the catalytic subunit of human telomerase, with potential immunostimulating and antineoplastic activities. hTERT I540/R572Y/D988Y multipeptide vaccine contains strongly antigenic peptide epitopes I540 (9-mer), R572Y (9-mer) and D988Y (10-mer). Vaccination with this agent may elicit a cytotoxic T cell (CTL) response against telomerase-expressing tumor cells. Directly linked to tumorigenesis, telomerase is expressed in the majority of human cancer cells but is infrequently expressed in normal cells.

Label: hTERT I540/R572Y/D988Y Multipeptide Vaccine

NCI Thesaurus Code: C71761 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL378528  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
hTERT I540/R572Y/D988Y Multipeptide Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 559159
PDQ Open Trial Search ID 559159 (check for NCI PDQ open clinical trial info)
NCI META CUI CL378528

Other Properties:
     Name Value (qualifiers indented underneath)
code C71761
Legacy_Concept_Name hTERT_I540_R572Y_D988Y_Multipeptide_Vaccine
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71761

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