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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Linifanib (Code C71759)

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Terms & Properties

Preferred Name: Linifanib

Definition: An orally bioavailable receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Linifanib inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families; it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. This agent does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as FMS-related tyrosine kinase receptor-3 (FLT3).

NCI-GLOSS Definition: A substance being studied in the treatment of several types of cancer. ABT-869 blocks the action of several growth factors. It may also block the growth of new blood vessels that tumors need to grow and may cause cancer cells to die. It is a type of receptor tyrosine kinase inhibitor and a type of angiogensis inhibitor.

Display Name: Linifanib

Label: Linifanib

NCI Thesaurus Code: C71759 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C4048786  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
multitargeted receptor tyrosine kinase inhibitor ABT-869

External Source Codes: 
CAS Registry Number 796967-16-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 558913
PDQ Open Trial Search ID 558913 (check for NCI PDQ open clinical trial info)
UMLS CUI C4048786

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H18FN5O
code C71759
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Receptor_Tyrosine_Kinase_Inhibitor_ABT-869
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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