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Version: 16.11d (Release date: 2016-11-28)
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S-Adenosyl-L-Methionine Disulfate P-Toluene-Sulfonate (Code C71745)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: S-Adenosyl-L-Methionine Disulfate P-Toluene-Sulfonate

Definition: The disulfate salt of the stable p-toluene-sulfonate complex of s-adenosyl-L-methionine (SAMe) with chemopreventive activity. SAMe disulfate p-toluene-sulfonate undergoes hydrolytic conversion to its active compound SAMe within cells. Although the mechanism of action is largely unknown, SAMe attenuates experimental liver damage and prevents experimental hepatocarcinogenesis. In addition, SAMe may reduce mitochondrial cytochrome C release, caspase 3 activation, and poly(ADP-ribose) polymerase cleavage, and attenuate okadaic acid-mediated hepatocyte apoptosis in a dose-dependent manner. SAMe is an essential compound in cellular transmethylation reactions and a precursor of polyamine and glutathione synthesis in the liver; SAMe deficiency is associated with chronic liver disease-associated decreases in the activity of methionine adenosyltransferase 1A (MAT1A), the enzyme that catalyzes the production of SAMe as the first step in methionine catabolism.

Display Name: S-Adenosyl-L-Methionine Disulfate P-Toluene-Sulfonate

Label: S-Adenosyl-L-Methionine Disulfate P-Toluene-Sulfonate

NCI Thesaurus Code: C71745 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376146  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(3S)-5'-((3-Amino-3-carboxypropyl)methylsulfonio)-5'-deoxyadenosine, Disulfate-methylbenzenesulfonate
S-Adenosyl-L-Methionine Disulfate P-Toluene-Sulfonate
S-Adenosyl-L-Methionine Disulfate p-Toluenesulfonate
S-Adenosyl-L-methionine Disulfate Tosilate
S-ADENOSYL-L-METHIONINE DISULFATE TOSYLATE
S-Adenosyl-L-methionine Disulfate Tosylate
S-adenosylmethionine Tosylate Disulfate
SAM-e Complete
SAMe Disulfate P-Toluene-Sulfonate

External Source Codes: 
FDA UNII Code 564ROC9U09
PDQ Closed Trial Search ID 560733
PDQ Open Trial Search ID 560733 (check for NCI PDQ open clinical trial info)
NCI META CUI CL376146

Other Properties:
Name Value (qualifiers indented underneath)
code C71745
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name S-Adenosyl-L-Methionine_Disulfate_P-Toluene-Sulfonate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71745

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