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Version: 16.11d (Release date: 2016-11-28)
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Enzalutamide (Code C71744)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Enzalutamide

Definition: An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance.

Display Name: Enzalutamide

Label: Enzalutamide

NCI Thesaurus Code: C71744 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2348174  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ASP9785
Benzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl-
Enzalutamide
ENZALUTAMIDE
MDV3100
Xtandi

External Source Codes: 
CAS Registry Number 915087-33-1 (see NLM ChemIDplus info)
FDA UNII Code 93T0T9GKNU
PDQ Closed Trial Search ID 560774
PDQ Open Trial Search ID 560774 (check for NCI PDQ open clinical trial info)
UMLS CUI C2348174

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Prostate cancer
Chemical_Formula C21H16F4N4O2S
code C71744
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Selective_Androgen_Receptor_Modulator_MDV3100
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71744

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