skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.12d (Release date: 2017-12-26)
SearchBox Top
SearchBox Bottom
Enzalutamide (Code C71744)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Enzalutamide

Definition: An orally bioavailable, organic, non-steroidal small molecule targeting the androgen receptor (AR) with potential antineoplastic activity. Through a mechanism that is reported to be different from other approved AR antagonists, enzalutamide inhibits the activity of prostate cancer cell ARs, which may result in a reduction in prostate cancer cell proliferation and, correspondingly, a reduction in the serum prostate specific antigen (PSA) level. AR over-expression in prostate cancer represents a key mechanism associated with prostate cancer hormone resistance.

Display Name: Enzalutamide

Label: Enzalutamide

NCI Thesaurus Code: C71744 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2348174  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Benzamide, 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxo-1-imidazolidinyl)-2-fluoro-N-methyl-

External Source Codes: 
CAS Registry Number 915087-33-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 560774
PDQ Open Trial Search ID 560774 (check for NCI PDQ open clinical trial info)
UMLS CUI C2348174

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Prostate cancer
Chemical_Formula C21H16F4N4O2S
code C71744
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Selective_Androgen_Receptor_Modulator_MDV3100
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom