skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
IL-2 Recombinant Fusion Protein ALT-801 (Code C71743)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: IL-2 Recombinant Fusion Protein ALT-801

Definition: A recombinant protein consisting of the cytokine interleukin-2 (IL-2) fused to a humanized soluble T-cell receptor (TCR) directed against a tumor suppressor p53-derived antigen with potential immunopotentiating and antineoplastic activities. The TCR moiety of IL-2 recombinant fusion protein ALT-801 binds to tumor cells displaying p53 epitope/MHC complexes; subsequently, the tumor cell-localized IL-2 moiety may stimulate natural killer (NK) cell and T cell cytotoxic immune responses against p53-expressing tumor cells.

Display Name: IL-2 Recombinant Fusion Protein ALT-801

Label: IL-2 Recombinant Fusion Protein ALT-801

NCI Thesaurus Code: C71743 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346454  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ALT-801
IL-2 Recombinant Fusion Protein ALT-801

External Source Codes: 
PDQ Closed Trial Search ID 560749
PDQ Open Trial Search ID 560749 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346454

Other Properties:
     Name Value (qualifiers indented underneath)
code C71743
Contributing_Source CTRP
Legacy_Concept_Name IL-2_Recombinant_Fusion_Protein_ALT-801
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71743

Mainbox Bottom