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Version: 16.11d (Release date: 2016-11-28)
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Nucleotide Analogue GS 9219 (Code C71742)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nucleotide Analogue GS 9219

Definition: A prodrug of the acyclic nucleoside phosphonate analogue 9-(2-phosphonylmethoxyethyl)guanine (PMEG) with potential antineoplastic activity. Formulated to selectively accumulate in lymphocytes, nucleotide analogue GS 9219 is converted to its active metabolite, PMEG diphosphate (PMEGpp), via enzymatic hydrolysis, deamination, and phosphorylation; subsequently, PMEGpp is incorporated into nascent DNA chains by DNA polymerases, which may result in the termination of DNA synthesis, S-phase cell cycle arrest, and the induction of apoptosis in susceptible lymphoma cell populations.

Display Name: Nucleotide Analogue GS 9219

Label: Nucleotide Analogue GS 9219

NCI Thesaurus Code: C71742 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376149  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
9-(2-phosphonylmethoxyethyl)guanine nucleotide analogue prodrug GS 9219
GS9219
Nucleotide Analogue GS 9219

External Source Codes: 
NSC Code 287459 (see NCI DTP info)
PDQ Closed Trial Search ID 560932
PDQ Open Trial Search ID 560932 (check for NCI PDQ open clinical trial info)
NCI META CUI CL376149

Other Properties:
Name Value (qualifiers indented underneath)
code C71742
Contributing_Source CTRP
Legacy_Concept_Name Nucleotide_Analogue_GS_9219
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71742

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