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Version: 16.11d (Release date: 2016-11-28)
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Apatorsen (Code C71740)

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Terms & Properties

Preferred Name: Apatorsen

Definition: A second-generation antisense oligonucleotide targeting heat shock protein 27 (Hsp27) with potential antitumor and chemosensitizing activities. Apatorsen suppresses tumor cell expression of Hsp27, which may induce tumor cell apoptosis and enhance tumor cell sensitivity to cytotoxic agents. Hsp27, a chaperone belonging to the small heat shock protein (sHsp) group of proteins, is a cytoprotective protein that supports cell survival under conditions of stress; it has been found to be over-expressed in a variety of human cancers.

Display Name: Apatorsen

Label: Apatorsen

NCI Thesaurus Code: C71740 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2348994  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Apatorsen
ISIS 306053
OGX-427

External Source Codes: 
CAS Registry Number 1002331-21-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 559200
PDQ Open Trial Search ID 559200 (check for NCI PDQ open clinical trial info)
UMLS CUI C2348994

Other Properties:
Name Value (qualifiers indented underneath)
code C71740
Contributing_Source CTRP
Legacy_Concept_Name Hsp27_Antisense_Oligonucleotide_OGX-427
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71740

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