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Version: 17.08d (Release date: 2017-08-28)
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Nifurtimox (Code C71734)

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Terms & Properties

Preferred Name: Nifurtimox

Definition: A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function.

Label: Nifurtimox

NCI Thesaurus Code: C71734 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0028073  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BAYER 2502
BAY 2502

External Source Codes: 
CAS Registry Number 23256-30-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 558911
PDQ Open Trial Search ID 558911 (check for NCI PDQ open clinical trial info)
UMLS CUI C0028073

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C10H13N3O5S
code C71734
Contributing_Source FDA
Legacy_Concept_Name Nifurtimox
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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