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Version: 16.10e (Release date: 2016-10-31)
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Nifurtimox (Code C71734)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nifurtimox

Definition: A nitrofuran derivative with antiprotozoal and potential antineoplastic activities. Nifurtimox is reduced by cytosol enzymes or flavin-containing microsomal enzymes to a highly reactive nitro anion free radical; autooxidation of the nitro anion free radical generates cytotoxic superoxide anion (02-). In addition, nifurtimox-derived nitro anion free radicals may alkylate macromolecules such as nucleic acids and proteins, resulting in the disruption of their structure and function.

Label: Nifurtimox

NCI Thesaurus Code: C71734 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0028073  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-((5-Nitrofurfurylidene)amino)-3-methylthiomorpholine-1,1-dioxide
BAYER 2502
BAY 2502
Lampit
NIFURTIMOX
Nifurtimox

External Source Codes: 
CAS Registry Number 23256-30-6 (see NLM ChemIDplus info)
FDA UNII Code M84I3K7C2O
PDQ Closed Trial Search ID 558911
PDQ Open Trial Search ID 558911 (check for NCI PDQ open clinical trial info)
UMLS CUI C0028073

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C10H13N3O5S
code C71734
Contributing_Source FDA
Legacy_Concept_Name Nifurtimox
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71734

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