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Version: 17.10e (Release date: 2017-10-30)
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Quarfloxin (Code C71726)

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Terms & Properties

Preferred Name: Quarfloxin

Definition: A fluoroquinolone derivative with antineoplastic activity. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA (rDNA) template, a critical interaction for rRNA biogenesis that is overexpressed in cancer cells; disruption of this G-quadruplex DNA:protein interaction in aberrant rRNA biogenesis may result in the inhibition of ribosome synthesis and tumor cell apoptosis.

Display Name: Quarfloxin

Label: Quarfloxin

NCI Thesaurus Code: C71726 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2713025  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
3H-Benzo(b)pyrido(3,2,1-kl)phenoxazine-2-carboxamide, 5-fluoro-N-(2-((2S)- 1-methyl-2-pyrrolidinyl)ethyl)-3-oxo-6-(3-pyrazinyl-1-pyrrolidinyl)-
5-Fluoro-N-(2-((2S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-(3-(pyrazin-2- yl)pyrrolidin-1-yl)-3H-benzo(b)pyrido(3,2,1-kl)phenoxazine-2-carboxamide

External Source Codes: 
CAS Registry Number 865311-47-3 (see NLM ChemIDplus info)
FDA UNII Code 8M31J5031Q
PDQ Closed Trial Search ID 558903
PDQ Open Trial Search ID 558903 (check for NCI PDQ open clinical trial info)
UMLS CUI C2713025

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C35H33FN6O3
code C71726
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Quarfloxacin
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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