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Version: 17.06d (Release date: 2017-06-26)
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Hypoxia-Activated Prodrug TH-302 (Code C71722)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Hypoxia-Activated Prodrug TH-302

Definition: A hypoxia-activated prodrug consisting of a 2-nitroimidazole phosphoramidate conjugate with potential antineoplastic activity. The 2-nitroimidazole moiety of hypoxia-activated prodrug TH-302 acts as a hypoxic trigger, releasing the DNA-alkylating dibromo isophosphoramide mustard moiety within hypoxic regions of tumors. Normoxic tissues may be spared due to the hypoxia-specific activity of this agent, potentially reducing systemic toxicity.

Display Name: Hypoxia-Activated Prodrug TH-302

Label: Hypoxia-Activated Prodrug TH-302

NCI Thesaurus Code: C71722 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2348906  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HAP TH-302
Hypoxia-Activated Prodrug TH-302
TH-302

External Source Codes: 
PDQ Closed Trial Search ID 560194
PDQ Open Trial Search ID 560194 (check for NCI PDQ open clinical trial info)
UMLS CUI C2348906

Other Properties:
     Name Value (qualifiers indented underneath)
code C71722
Contributing_Source CTRP
Legacy_Concept_Name HAP_TH-302
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71722

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