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Version: 17.06d (Release date: 2017-06-26)
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Olaparib (Code C71721)

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Terms & Properties

Preferred Name: Olaparib

Definition: A small molecule inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. Olaparib selectively binds to and inhibits PARP, inhibiting PARP-mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA-damaging agents and may reverse tumor cell chemoresistance and radioresistance. PARP catalyzes post-translational ADP-ribosylation of nuclear proteins and can be activated by single-stranded DNA breaks.

NCI-GLOSS Definition: A substance being studied in the treatment of breast, ovarian, and prostate cancers caused by mutations (changes) in the BRCA1 and BRCA2 genes. It is also being studied in the treatment of other types of cancer. It blocks an enzyme involved in many functions of the cell, including the repair of DNA damage. DNA damage may be caused by normal cell actions, UV light, some anticancer drugs, and radiation used to treat cancer. AZD2281 may cause cancer cells to die. It is a type of targeted therapy agent and a type of poly (ADP-ribose) polymerase inhibitor.

Display Name: Olaparib

Label: Olaparib

NCI Thesaurus Code: C71721 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2316164  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD2281
KU-0059436
Lynparza
Olaparib
OLAPARIB
olaparib
PARP Inhibitor AZD2281
PARP inhibitor AZD2281

External Source Codes: 
CAS Registry Number 763113-22-0 (see NLM ChemIDplus info)
FDA UNII Code WOH1JD9AR8
PDQ Closed Trial Search ID 560191
PDQ Open Trial Search ID 560191 (check for NCI PDQ open clinical trial info)
UMLS CUI C2316164

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H23FN4O3
code C71721
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name PARP_Inhibitor_AZD2281
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71721

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