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Version: 16.11d (Release date: 2016-11-28)
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Pegylated Granulocyte Colony Stimulating Factor MAXY-G34 (Code C71718)

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Terms & Properties

Preferred Name: Pegylated Granulocyte Colony Stimulating Factor MAXY-G34

Definition: A long-acting, pegylated recombinant variant of human granulocyte colony-stimulating factor (G-CSF) with immunomodulating activity. Pegylated granulocyte colony stimulating factor MAXY-G34 contains multiple non-naturally occurring lysines that have been introduced into alpha helixes of wild type human G-CSF as pegylation sites; other naturally occurring lysine residues have been removed to prevent pegylation and the variant G-CSF is pegylated with methoxypolyethylene glycol succinimidyl propionate (mPEG SPA) at three amino acid residues. Similar to endogenous G-CSF, this agent binds to and activates specific cell surface receptors, stimulating neutrophil progenitor proliferation and differentiation and selected neutrophil functions. A difference in the degree of pegylation may account for the extended half-life of this agent compared to pegfilgrastim which is pegylated at only one amino acid residue.

Label: Pegylated Granulocyte Colony Stimulating Factor MAXY-G34

NCI Thesaurus Code: C71718 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2347460  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MAXY-G34
PEG-GCSF MAXY-G34
Pegylated Granulocyte Colony Stimulating Factor MAXY-G34

External Source Codes: 
PDQ Closed Trial Search ID 561025
PDQ Open Trial Search ID 561025 (check for NCI PDQ open clinical trial info)
UMLS CUI C2347460

Other Properties:
Name Value (qualifiers indented underneath)
code C71718
Legacy_Concept_Name Pegylated_G-SCF_MAXY-G34
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71718

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