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Version: 17.06d (Release date: 2017-06-26)
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Givinostat (Code C71716)

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Terms & Properties

Preferred Name: Givinostat

Definition: An orally bioavailable hydroxymate inhibitor of histone deacetylase (HDAC) with potential anti-inflammatory, anti-angiogenic, and antineoplastic activities. Givinostat inhibits class I and class II HDACs, resulting in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. At low, nonapoptotic concentrations, this agent inhibits the production of pro-inflammatory cytokines such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1), IL-6 and interferon-gamma. Givinostat has also been shown to activate the intrinsic apoptotic pathway, inducing apoptosis in hepatoma cells and leukemic cells. This agent may also exhibit anti-angiogenic activity, inhibiting the production of angiogenic factors such as IL-6 and vascular endothelial cell growth factor (VEGF) by bone marrow stromal cells.

Label: Givinostat

NCI Thesaurus Code: C71716 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2987670  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Gavinostat
GIVINOSTAT
Givinostat
ITF2357

External Source Codes: 
CAS Registry Number 497833-27-9 (see NLM ChemIDplus info)
FDA UNII Code 5P60F84FBH
PDQ Closed Trial Search ID 560751
PDQ Open Trial Search ID 560751 (check for NCI PDQ open clinical trial info)
UMLS CUI C2987670

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C24H27N3O4
code C71716
Contributing_Source FDA
Legacy_Concept_Name HDAC_Inhibitor_ITF2357
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71716

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