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Version: 17.06d (Release date: 2017-06-26)
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Pan-AKT Kinase Inhibitor GSK690693 (Code C71711)

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Terms & Properties

Preferred Name: Pan-AKT Kinase Inhibitor GSK690693

Definition: An aminofurazan-derived inhibitor of Akt kinases with potential antineoplastic activity. Pan-AKT kinase inhibitor GSK-690693 binds to and inhibits Akt kinases 1, 2, and 3, which may result in the inhibition of protein phosphorylation events downstream from Akt kinases in the PI3K/Akt signaling pathway, and, subsequently, the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. In addition, this agent may inhibit other protein kinases including protein kinase C (PKC) and protein kinase A (PKA). As serine/threonine protein kinases which are involved in a number of biological processes, AKT kinases promote cell survival by inhibiting apoptosis and are required for glucose transport.

Display Name: Pan-AKT Kinase Inhibitor GSK690693

Label: Pan-AKT Kinase Inhibitor GSK690693

NCI Thesaurus Code: C71711 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2347443  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Pan-AKT Kinase Inhibitor GSK690693

External Source Codes: 
PDQ Closed Trial Search ID 560189
PDQ Open Trial Search ID 560189 (check for NCI PDQ open clinical trial info)
UMLS CUI C2347443

Other Properties:
     Name Value (qualifiers indented underneath)
code C71711
Contributing_Source CTRP
Legacy_Concept_Name Pan-AKT_Inhibitor_GSK-690693
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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