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Version: 17.06d (Release date: 2017-06-26)
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Receptor Tyrosine Kinase Inhibitor R1530 (Code C71710)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Receptor Tyrosine Kinase Inhibitor R1530

Definition: A pyrazolobenzodiazepine small molecule with potential antiangiogenesis and antineoplastic activities. Mitosis-angiogenesis inhibitor (MAI) R1530 inhibits multiple receptor tyrosine kinases involved in angiogenesis, such as vascular endothelial growth factor receptor (VEGFR)-1, -2, -3, platelet-derived growth factor receptor (PDGFR) beta, FMS-like tyrosine kinase (Flt)-3, and fibroblast growth factor receptor (FGFR) -1, -2. In addition, this agents exhibits anti-proliferative activity by initiating mitotic arrest and inducing apoptosis.

Display Name: Receptor Tyrosine Kinase Inhibitor R1530

Label: Receptor Tyrosine Kinase Inhibitor R1530

NCI Thesaurus Code: C71710 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376137  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MAI R1530
R1530
Receptor Tyrosine Kinase Inhibitor R1530

External Source Codes: 
PDQ Closed Trial Search ID 560180
PDQ Open Trial Search ID 560180 (check for NCI PDQ open clinical trial info)
NCI META CUI CL376137

Other Properties:
     Name Value (qualifiers indented underneath)
code C71710
Contributing_Source CTRP
Legacy_Concept_Name Mitosis_and_Apoptosis_Inhibitor_R1530
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71710

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