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Version: 17.06d (Release date: 2017-06-26)
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Nanoparticle Albumin-Bound Docetaxel (Code C71696)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nanoparticle Albumin-Bound Docetaxel

Definition: A nanoparticle albumin-bound formulation of the taxane docetaxel with antineoplastic activity. Docetaxel is a semi-synthetic, second-generation taxane derived from a compound found in the European yew tree Taxus baccata. Docetaxel binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell-cycle arrest at the G2/M phase and cell death. This agent also inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and displays immunomodulatory and pro-inflammatory properties by inducing various mediators of the inflammatory response. This nanoparticle albumin-bound formulation solubilizes docetaxel without the use of the nonionic solubilizer Cremophor ELP, permitting the administration of larger doses of docetaxel while avoiding Cremophor ELP-associated toxicity.

Display Name: Nanoparticle Albumin-Bound Docetaxel

Label: Nanoparticle Albumin-Bound Docetaxel

NCI Thesaurus Code: C71696 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376119  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ABI-008
Nab-Docetaxel
Nanoparticle Albumin-Bound Docetaxel

External Source Codes: 
PDQ Closed Trial Search ID 557567
PDQ Open Trial Search ID 557567 (check for NCI PDQ open clinical trial info)
NCI META CUI CL376119

Other Properties:
     Name Value (qualifiers indented underneath)
code C71696
Contributing_Source CTRP
Legacy_Concept_Name Nanoparticle_Albumin-Bound_Docetaxel
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71696

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