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Version: 17.06d (Release date: 2017-06-26)
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PGLA/PEG Copolymer-Based Paclitaxel (Code C71692)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: PGLA/PEG Copolymer-Based Paclitaxel

Definition: A controlled-release, intratumoral paclitaxel formulation in which paclitaxel is incorporated into a thermosensitive, biodegradable triblock copolymer consisting of poly(lactide-co-glycolide) (PLGA) and polyethylene glycol (PEG). Upon intratumoral injection, paclitaxel is released slowly and continuously into tumor tissues from the gelled thermosensitive triblock copolymer over a period of 4 to 6 weeks; in tumor cells, paclitaxel binds to tubulin and inhibits the disassembly-assembly dynamics of microtubules, resulting in cell cycle arrest and cell death. The thermosensitive triblock copolymer component of this formulation transforms from a water-soluble polymer at room temperature to a water-insoluble, biodegradable gel depot at body temperature; intratumoral controlled-release of paclitaxel from the gel minimizes systemic exposure to paclitaxel and the paclitaxel toxicity profile.

Display Name: PGLA/PEG Copolymer-Based Paclitaxel

Label: PGLA/PEG Copolymer-Based Paclitaxel

NCI Thesaurus Code: C71692 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376115  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
OncoGel
PGLA/PEG Copolymer-Based Paclitaxel

External Source Codes: 
PDQ Closed Trial Search ID 555445
PDQ Open Trial Search ID 555445 (check for NCI PDQ open clinical trial info)
NCI META CUI CL376115

Other Properties:
     Name Value (qualifiers indented underneath)
code C71692
Contributing_Source CTRP
Legacy_Concept_Name PGLA_PEG_Copolymer-Based_Paclitaxel
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71692

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