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Version: 16.11d (Release date: 2016-11-28)
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Omeprazole (Code C716)

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Terms & Properties

Preferred Name: Omeprazole

Definition: A benzimidazole with selective and irreversible proton pump inhibition activity. Omeprazole forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. This agent exhibits no anticholinergic activities and does not antagonize histamine H2 receptors.

NCI-GLOSS Definition: A drug that inhibits gastric acid secretion.

Display Name: Omeprazole

Label: Omeprazole

NCI Thesaurus Code: C716 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0028978  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-Methoxy-2-(((4-methoxy-3,5-dimethyl-2-pyridinyl)methyl)sulfinyl)-1H-benzimidazole
H168/68
Losec
OMEP
Omeprazole
OMEPRAZOLE
omeprazole
Prilosec

External Source Codes: 
CAS Registry Number 73590-58-6 (see NLM ChemIDplus info)
FDA UNII Code KG60484QX9
ChEBI ID CHEBI:7772 (see ChEBI info)
PDQ Closed Trial Search ID 42309
PDQ Open Trial Search ID 42309 (check for NCI PDQ open clinical trial info)
UMLS CUI C0028978

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C17H19N3O3S
code C716
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Omeprazole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C716

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