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Version: 16.11d (Release date: 2016-11-28)
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Inotuzumab Ozogamicin (Code C71542)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Inotuzumab Ozogamicin

Definition: A CD22-targeted cytotoxic immunoconjugate composed of a humanized IgG4 anti-CD22 antibody covalently linked to N-acetyl-gamma-calicheamicin dimethyl hydrazide (CalichDMH) with potential antineoplastic activity. Inotuzumab ozogamicin is rapidly internalized upon binding of the antibody moiety to B cell-specific CD22 receptors, delivering the conjugated CalichDMH intracellularly; the CalichDMH moiety binds to the minor groove of DNA in a sequence-specific manner, resulting in double-strand DNA breaks and apoptosis. CalichDMH is a derivative of gamma calicheamicin, a cytotoxic antibiotic produced by the bacterium Micromonospora echinospora.

Display Name: Inotuzumab Ozogamicin

Label: Inotuzumab Ozogamicin

NCI Thesaurus Code: C71542 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1567130  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CMC-544
Inotuzumab Ozogamicin
INOTUZUMAB OZOGAMICIN
WAY-207294
Way 207294

External Source Codes: 
CAS Registry Number 635715-01-4 (see NLM ChemIDplus info)
FDA UNII Code P93RUU11P7
PDQ Closed Trial Search ID 352004
PDQ Open Trial Search ID 352004 (check for NCI PDQ open clinical trial info)
UMLS CUI C1567130

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C73H96IN6O25S3
code C71542
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-CD22-CalichDMH_Conjugate
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71542

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