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Version: 17.06d (Release date: 2017-06-26)
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Allogeneic CD4+ Memory Th1-like T Cells/Microparticle-bound Anti-CD3/anti-CD28 (Code C71540)

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Terms & Properties

Preferred Name: Allogeneic CD4+ Memory Th1-like T Cells/Microparticle-bound Anti-CD3/anti-CD28

Definition: A preparation consisting of allogeneic, differentiated Th1-like T cells bound to T cell-stimulating monoclonal antibodies with potential antitumor activity. More specifically, allogeneic CD4+ memory Th1-like T cells/microparticle-bound anti-CD3/anti-CD28 are composed of a proprietary preparation of mismatched, allogeneic differentiated CD4+ memory Th1-like T cells bound to paramagnetic, epoxy-covered 4.5 micron microparticles with covalently bound anti-CD3/anti-CD28 monoclonal antibodies at a 2:1 bead:cell ratio. The CD4+ memory Th1-like T cells are derived from precursors found in the circulation of a normal donor. Stimulated by the microparticle-bound monoclonal antibodies, the infused T cells produce pro-inflammatory, anti-tumor cytokines such as like IFN-gamma, TNF-beta, and IL-2, disabling tumor immune avoidance mechanisms and stimulating the host immune system to both reject the infused T cells and kill tumor cells.

Label: Allogeneic CD4+ Memory Th1-like T Cells/Microparticle-bound Anti-CD3/anti-CD28

NCI Thesaurus Code: C71540 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL378252  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Allogeneic CD4+ Memory Th1-like T Cells/Microparticle-bound Anti-CD3/anti-CD28
AlloStim

External Source Codes: 
PDQ Closed Trial Search ID 580835
PDQ Open Trial Search ID 580835 (check for NCI PDQ open clinical trial info)
NCI META CUI CL378252

Other Properties:
     Name Value (qualifiers indented underneath)
code C71540
Legacy_Concept_Name Allogeneic_CD4_Specific_Memory_Th1-Like_T_Cell
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71540

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