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Version: 16.11d (Release date: 2016-11-28)
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Acadesine (Code C71537)

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Terms & Properties

Preferred Name: Acadesine

Definition: A 5-aminoimidazole-4-carboxamide (AICA) riboside, a ribnucleoside analog, and a nucleotide biosynthesis precursor with B cell pro-apoptotic activity. Following cellular uptake, acadesine is phosphorylated to AICA ribotide (ZMP), which mimics 5'-adenosine monophosphate (AMP). Both AMP-activated protein kinase (AMPK) and AMPK kinase (AMPKK) are activated by ZMP, which appears to be necessary for the induction of apoptosis. Acadesine-induced apoptosis also appears to require cytochrome c release from mitochondria and caspase activation and is p53-independent. However, the exact mechanism of acadesine-induced apoptosis is unknown. T cells are significantly less susceptible than B cells to acadesine-induced apoptosis. AMPK regulates several cellular systems including the cellular uptake of glucose, the beta-oxidation of fatty acids, protein synthesis, and the biogenesis of glucose transporter 4 (GLUT4) and mitochondria.

Label: Acadesine

NCI Thesaurus Code: C71537 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0051027  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-Amino-1beta-D-ribofuranosylimidazole-4-carboxyamide
5-Amino-4-imidazolecarboxamide Ribofuranoside
ACADESINE
Acadesine
AICA-riboside
Arasine
GP-1-110
Protara

External Source Codes: 
CAS Registry Number 2627-69-2 (see NLM ChemIDplus info)
FDA UNII Code 53IEF47846
NSC Code 105823 (see NCI DTP info)
PDQ Closed Trial Search ID 580838
PDQ Open Trial Search ID 580838 (check for NCI PDQ open clinical trial info)
UMLS CUI C0051027

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C9H14N4O5
code C71537
Contributing_Source FDA
Legacy_Concept_Name Acadesine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71537

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