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Version: 17.12d (Release date: 2017-12-26)
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EGFRBi-Armed Autologous T Cells (Code C71536)

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Terms & Properties

Preferred Name: EGFRBi-Armed Autologous T Cells

Definition: Autologous activated T cells, loaded with a bispecific antibody produced by heteroconjugation of anti-CD3 and anti-epidermal growth factor receptor (EGFR) monoclonal antibodies, with potential antineoplastic activity. Binding of EGFRBi-armed autologous activated T cells to EGFR-positive tumor cells may result in increased T cell-mediated cytotoxicity towards tumor cells expressing EGFR. Arming activated T cells with this bispecific antibody may significantly increase T cell secretion of anti-tumor associated cytokines such as IL2, RANTES, IFN-gamma, and TNF-alpha.

Display Name: EGFRBi-Armed Autologous T Cells

Label: EGFRBi-Armed Autologous T Cells

NCI Thesaurus Code: C71536 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL378020  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EGFRBi-Armed Autologous T Cells

External Source Codes: 
PDQ Closed Trial Search ID 579877
PDQ Open Trial Search ID 579877 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C71536
Contributing_Source CTRP
Legacy_Concept_Name EGFRBi-Armed_Autologous_T_Cell
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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