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Version: 17.06d (Release date: 2017-06-26)
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Indoximod (Code C71535)

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Terms & Properties

Preferred Name: Indoximod

Definition: A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.

NCI-GLOSS Definition: A substance being studied in the treatment of melanoma and many other types of cancer. 1-methyl-d-tryptophan blocks the breakdown of the amino acid tryptophan, which is needed for T cells (a type of immune system cell) to kill tumor cells. Giving 1-methyl-d-tryptophan to patients who have received chemotherapy for cancer may help kill more tumor cells. It is a type of enzyme inhibitor and immunosuppressant.

Display Name: Indoximod

Label: Indoximod

NCI Thesaurus Code: C71535 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C4045546  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-methyl-d-tryptophan
1-Methyl-D-tryptophan
1-MT
D-(+)-1-Methyltryptophan
D-1MT
Indoximod
INDOXIMOD

External Source Codes: 
FDA UNII Code TX5CYN1KMZ
PDQ Closed Trial Search ID 579646
PDQ Open Trial Search ID 579646 (check for NCI PDQ open clinical trial info)
UMLS CUI C4045546

Other Properties:
     Name Value (qualifiers indented underneath)
code C71535
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name _1-Methyl-d-Tryptophan
Semantic_Type Chemical Viewed Functionally

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71535

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