|Indoximod (Code C71535)|
|Terms & Properties|
Preferred Name: Indoximod
Definition: A methylated tryptophan with immune checkpoint inhibitory activity. Indoximod inhibits the enzyme indoleamine 2,3-dioxygenase (IDO), which degrades the essential amino acid tryptophan, and may increase or maintain tryptophan levels important to T cell function. Tryptophan depletion is associated with immunosuppression involving T cell arrest and anergy.
NCI-GLOSS Definition: A substance being studied in the treatment of melanoma and many other types of cancer. 1-methyl-d-tryptophan blocks the breakdown of the amino acid tryptophan, which is needed for T cells (a type of immune system cell) to kill tumor cells. Giving 1-methyl-d-tryptophan to patients who have received chemotherapy for cancer may help kill more tumor cells. It is a type of enzyme inhibitor and immunosuppressant.
Display Name: Indoximod
NCI Metathesaurus Link: C4045546 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|FDA UNII Code||TX5CYN1KMZ|
|PDQ Closed Trial Search ID||579646|
|PDQ Open Trial Search ID||579646 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
|Semantic_Type||Chemical Viewed Functionally|
Additional Concept Data:
|Defined Fully by Roles: No|