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Version: 17.06d (Release date: 2017-06-26)
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Pexastimogene-devacirepvec (Code C71533)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pexastimogene-devacirepvec

Definition: A thymidine kinase-deleted vaccinia virus expressing human GM-CSF (hGM-CSF) with oncolytic activity. Upon intratumoral or intravenous administration, pexastimogene-devacirepvec may selectively infect and lyse tumor cells. While vaccinia displays a natural tumor cell tropism, deletion of the thymidine kinase gene increases the tumor selectivity of vaccinia by limiting viral replication to transformed cells. hGM-CSF expression by this agent may help recruit antigen processing cells (APCs), such as denritic cells and macrophages, to virally infected tumor cells, initiating a systemic antitumoral immune response.

Display Name: Pexastimogene-devacirepvec

Label: Pexastimogene-devacirepvec

NCI Thesaurus Code: C71533 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL378156  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
JX-594
Pexastimogene-devacirepvec
Thymidine Kinase-(-) Vaccinia-GM-CSF JX-594 Vaccine

External Source Codes: 
CAS Registry Number 1058624-46-6 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 579292
PDQ Open Trial Search ID 579292 (check for NCI PDQ open clinical trial info)
NCI META CUI CL378156

Other Properties:
     Name Value (qualifiers indented underneath)
code C71533
Contributing_Source CTRP
Legacy_Concept_Name Thymidine_Kinase-Deleted_Vaccinia-GM-CSF_JX-594_Vaccine
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71533

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