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Version: 16.10e (Release date: 2016-10-31)
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Ganitumab (Code C71531)

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Terms & Properties

Preferred Name: Ganitumab

Definition: A recombinant, fully human monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Ganitumab binds to membrane-bound IGF-1R, preventing binding of the ligand IGF-1 and the subsequent triggering of the PI3K/Akt signaling pathway; inhibition of this survival signaling pathway may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a tyrosine kinase and a member of the insulin receptor family. IGF-1R activation stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been highly implicated in tumorigenesis and metastasis.

Display Name: Ganitumab

Label: Ganitumab

NCI Thesaurus Code: C71531 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2744646  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMG 479
Anti-IGF-1R Human Monoclonal Antibody AMG-479
Ganitumab
GANITUMAB

External Source Codes: 
CAS Registry Number 905703-97-1 (see NLM ChemIDplus info)
FDA UNII Code CK1441RCZ8
PDQ Closed Trial Search ID 578040
PDQ Open Trial Search ID 578040 (check for NCI PDQ open clinical trial info)
UMLS CUI C2744646

Other Properties:
Name Value (qualifiers indented underneath)
code C71531
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-IGF-1R_Human_Monoclonal_Antibody_AMG-479
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71531

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