skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.10e (Release date: 2017-10-30)
SearchBox Top
SearchBox Bottom
Ganitumab (Code C71531)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ganitumab

Definition: A recombinant, fully human monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Ganitumab binds to membrane-bound IGF-1R, preventing binding of the ligand IGF-1 and the subsequent triggering of the PI3K/Akt signaling pathway; inhibition of this survival signaling pathway may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. IGF-1R is a tyrosine kinase and a member of the insulin receptor family. IGF-1R activation stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been highly implicated in tumorigenesis and metastasis.

Display Name: Ganitumab

Label: Ganitumab

NCI Thesaurus Code: C71531 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2744646  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMG 479
Anti-IGF-1R Human Monoclonal Antibody AMG-479

External Source Codes: 
CAS Registry Number 905703-97-1 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 578040
PDQ Open Trial Search ID 578040 (check for NCI PDQ open clinical trial info)
UMLS CUI C2744646

Other Properties:
     Name Value (qualifiers indented underneath)
code C71531
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-IGF-1R_Human_Monoclonal_Antibody_AMG-479
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom