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Version: 17.06d (Release date: 2017-06-26)
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Serine/Threonine Kinase Inhibitor CBP501 (Code C71529)

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Terms & Properties

Preferred Name: Serine/Threonine Kinase Inhibitor CBP501

Definition: A peptide with G2 checkpoint-abrogating activity. G2 checkpoint inhibitor CBP501 inhibits multiple serine/threonine kinases, including MAPKAP-K2, C-Tak1, and CHK1, that phosphorylate serine 216 of the dual-specific phosphatase Cdc25C (cell division checkpoint 25 C); disruption of Cdc25C activity results in the inhibition of Cdc25C dephosphorylation of the mitotic cyclin-dependent kinase complex Cdc2/cyclin B, preventing entry into the mitotic phase of the cell cycle.

Display Name: Serine/Threonine Kinase Inhibitor CBP501

Label: Serine/Threonine Kinase Inhibitor CBP501

NCI Thesaurus Code: C71529 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2348193  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Serine/Threonine Kinase Inhibitor CBP501

External Source Codes: 
PDQ Closed Trial Search ID 577812
PDQ Open Trial Search ID 577812 (check for NCI PDQ open clinical trial info)
UMLS CUI C2348193

Other Properties:
     Name Value (qualifiers indented underneath)
code C71529
Contributing_Source CTRP
Legacy_Concept_Name Serine_Threonine_Kinase_Inhibitor_CBP501
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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