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Version: 16.11d (Release date: 2016-11-28)
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Bromovinyl-Deoxyuridine (Code C71528)

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Terms & Properties

Concept Status: Retired Concept  (See:  Brivudine )

Preferred Name: Bromovinyl-Deoxyuridine

Definition: A uridine derivative and nucleoside analog with pro-apoptotic and chemosensitizing properties. In vitro, bromovinyl-deoxyuridine (BVDU) has been shown to downregulate the multifunctional DNA repair enzyme APEX nuclease 1, resulting in the inhibition of DNA repair and the induction of apoptosis. In addition, this agent may inhibit the expression of STAT3 (signal transducer and activator of transcription 3), which may result in the downregulation of vascular endothelial growth factor (VEGF). BVDU has also been found to inhibit the upregulation of chemoresistance genes (Mdr1 and DHFR) during chemotherapy. Overall, the gene expression changes associated with BVDU treatment result in the decrease or prevention of chemoresistance. In addition, this agent has been shown to enhance the cytolytic activity of NK-92 natural killer cells towards a pancreatic cancer cell line in vitro.

Label: Bromovinyl-Deoxyuridine

NCI Thesaurus Code: C71528 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL378100  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bromovinyl-Deoxyuridine

External Source Codes: 
PDQ Closed Trial Search ID 577369
PDQ Open Trial Search ID 577369 (check for NCI PDQ open clinical trial info)
NCI META CUI CL378100

Other Properties:
Name Value (qualifiers indented underneath)
code C71528
Concept_Status Retired_Concept
DesignNote Mon Feb 20 13:22:43 EST 2012 - See 'Brivudine'
Legacy_Concept_Name Bromovinyl-Deoxyuridine
OLD_PARENT Enzyme_Inhibitor
Semantic_Type Chemical Viewed Functionally

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71528

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