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Version: 17.06d (Release date: 2017-06-26)
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Robatumumab (Code C71527)

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Terms & Properties

Preferred Name: Robatumumab

Definition: A recombinant, fully human monoclonal antibody directed against the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Anti-IGF-1R fully human monoclonal antibody SCH 717454 binds to membrane-bound IGF-1R, preventing binding of the ligand IGF-1 and the subsequent triggering of the PI3K/Akt signaling pathway; downregulation of this survival pathway may result in the induction of apoptosis and decreased cellular proliferation. The activation of IGF-1R, a tyrosine kinase and a member of the insulin receptor family, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been highly implicated in tumorigenesis and metastasis.

Display Name: Robatumumab

Label: Robatumumab

NCI Thesaurus Code: C71527 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3467798  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-IGF-1R Recombinant Monoclonal Antibody SCH 717454
Immunoglobulin G1, Anti-(Human Insulin-Like Growth Factor I Receptor) (Human Monoclonal SCH 717454 Heavy Chain), Disulfide with Human Monoclonal SCH 717454 Light Chain, Dimer
Robatumumab
ROBATUMUMAB
Sch717454

External Source Codes: 
CAS Registry Number 934235-44-6 (see NLM ChemIDplus info)
FDA UNII Code V983921H3B
PDQ Closed Trial Search ID 577364
PDQ Open Trial Search ID 577364 (check for NCI PDQ open clinical trial info)
UMLS CUI C3467798

Other Properties:
     Name Value (qualifiers indented underneath)
code C71527
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-IGF-1R_Recombinant_Monoclonal_Antibody_SCH_717454
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71527

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