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Version: 17.06d (Release date: 2017-06-26)
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Folate Receptor Targeted Epothilone BMS753493 (Code C71524)

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Terms & Properties

Preferred Name: Folate Receptor Targeted Epothilone BMS753493

Definition: A folate receptor-targeting antimitotic agent with potential antineoplastic activity. Folate receptor-targeted epothilone BMS753493 contains an epothilone moiety linked to a single folate molecule. Mediated through the folate moiety, this agent delivers the antimitotic epothilone component into cells expressing folic acid receptors, frequently upregulated in many types of tumor cells. After ligand-receptor internalization, the epothilone moiety induces microtubule polymerization and stabilizes microtubules against depolymerization, resulting in the inhibition of mitosis and cellular proliferation.

Display Name: Folate Receptor Targeted Epothilone BMS753493

Label: Folate Receptor Targeted Epothilone BMS753493

NCI Thesaurus Code: C71524 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376231  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Folate Receptor Targeted Epothilone BMS753493

External Source Codes: 
PDQ Closed Trial Search ID 575735
PDQ Open Trial Search ID 575735 (check for NCI PDQ open clinical trial info)
NCI META CUI CL376231

Other Properties:
     Name Value (qualifiers indented underneath)
code C71524
Contributing_Source CTRP
Legacy_Concept_Name Folate_Receptor-Targeted_Epothilone_BMS753493
Semantic_Type Chemical Viewed Structurally

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71524

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