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Version: 16.11d (Release date: 2016-11-28)
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Tanezumab (Code C71522)

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Terms & Properties

Preferred Name: Tanezumab

Definition: A humanized monoclonal antibody directed against nerve growth factor (NGF), a modulator of nociceptor function, with potential analgesic activity. Tanezumab binds to NGF and prevents NGF binding to its high affinity, membrane-bound, catalytic receptor tropomyosin-related kinase A (TrkA), which is present on sympathetic and sensory neurons; reduced stimulation of TrkA by NGF inhibits the pain-transmission activities of these neurons. NGF, a neurotrophin, is critical to the growth and maintenance of sympathetic and sensory neurons. In addition, NGF may induce mast cells to release inflammatory proteins and may induce the upregulation of substance P and other pain-related peptides in sympathetic and sensory neurons. Upon neurotrophin binding, TrkA phosphorylates itself and members of the MAPK pathway, mediating the multiple neuronal effects of NGF.

Display Name: Tanezumab

Label: Tanezumab

NCI Thesaurus Code: C71522 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346819  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-NGF Monoclonal Antibody RN624
PF-4383119
RN624
Tanezumab
TANEZUMAB

External Source Codes: 
CAS Registry Number 880266-57-9 (see NLM ChemIDplus info)
FDA UNII Code EQL0E9GCX1
PDQ Closed Trial Search ID 575320
PDQ Open Trial Search ID 575320 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346819

Other Properties:
Name Value (qualifiers indented underneath)
code C71522
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-NGF_Monoclonal_Antibody_RN624
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71522

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