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Version: 16.10e (Release date: 2016-10-31)
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SN-38-Loaded Polymeric Micelles NK012 (Code C71521)

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Terms & Properties

Preferred Name: SN-38-Loaded Polymeric Micelles NK012

Definition: A formulation consisting of polymeric micelles loaded with the irinotecan metabolite SN-38 with potential antineoplastic activity. SN-38-loaded polymeric micelles NK012 is an SN-38-releasing nanodevice constructed by covalently attaching SN-38 to the block copolymer PEG-PGlu, followed by self-assembly of amphiphilic block copolymers in an aqueous milieu. SN-38 (7-ethyl-10-hydroxy-camptothecin), a biological active metabolite of the prodrug irinotecan (CPT-11), binds to and inhibits topoisomerase I by stabilizing the cleavable complex between topoisomerase I and DNA, resulting in DNA breaks, inhibition of DNA replication, and apoptosis. SN-38 has been reported to exhibit up to 1,000-fold more cytotoxic activity against various cancer cells in vitro than irinotecan. This formulation increases the water-solubility of SN-38 and allows the delivery of higher doses of SN-38 than those achievable with SN-38 alone.

Label: SN-38-Loaded Polymeric Micelles NK012

NCI Thesaurus Code: C71521 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376227  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
NK012
SN-38-Loaded Polymeric Micelles NK012

External Source Codes: 
PDQ Closed Trial Search ID 574615
PDQ Open Trial Search ID 574615 (check for NCI PDQ open clinical trial info)
NCI META CUI CL376227

Other Properties:
Name Value (qualifiers indented underneath)
code C71521
Legacy_Concept_Name SN-38-Loaded_Polymeric_Micelle
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71521

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