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Version: 17.06d (Release date: 2017-06-26)
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Hsp90 Inhibitor AUY922 (Code C71467)

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Terms & Properties

Preferred Name: Hsp90 Inhibitor AUY922

Definition: A derivative of 4,5-diarylisoxazole and a third-generation heat shock protein 90 (Hsp90) inhibitor with potential antineoplastic activity. Hsp90 inhibitor AUY922 has been shown to bind with high affinity to and inhibit Hsp90, resulting in the proteasomal degradation of oncogenic client proteins; the inhibition of cell proliferation; and the elevation of heat shock protein 72 (Hsp72) in a wide range of human tumor cell lines. Hsp90, a 90 kDa molecular chaperone, plays a key role in the conformational maturation, stability and function of other substrate or "client" proteins within the cell, many of which are involved in signal transduction, cell cycle regulation and apoptosis, including kinases, transcription factors and hormone receptors. Hsp72 exhibits anti-apoptotic functions; its up-regulation may be used as a surrogate marker for Hsp90 inhibition.

Display Name: Hsp90 Inhibitor AUY922

Label: Hsp90 Inhibitor AUY922

NCI Thesaurus Code: C71467 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2348996  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AUY922
Hsp90 Inhibitor AUY922

External Source Codes: 
CAS Registry Number 747412-64-2 (see NLM ChemIDplus info)
FDA UNII Code G1G66XE93W
PDQ Closed Trial Search ID 570982
PDQ Open Trial Search ID 570982 (check for NCI PDQ open clinical trial info)
UMLS CUI C2348996

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C27H33N3O5
code C71467
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Hsp90_Inhibitor_AUY922
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71467

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