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Version: 17.06d (Release date: 2017-06-26)
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Rigosertib Sodium (Code C71355)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Rigosertib Sodium

Definition: A synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo-like kinase 1 inhibitor ON 01910.Na inhibits polo-like kinase1 (Plk1), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It blocks certain proteins that are needed for cell growth and may kill cancer cells. ON 01910.Na is a type of protein kinase inhibitor and a type of benzyl styryl sulfone analog.

Display Name: Rigosertib Sodium

Label: Rigosertib Sodium

NCI Thesaurus Code: C71355 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3467794  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ON 01910.Na
Polo-like kinase 1 Inhibitor ON 01910.Na
Rigosertib Sodium

External Source Codes: 
CAS Registry Number 592542-60-4 (see NLM ChemIDplus info)
FDA UNII Code 406FL5G00V
PDQ Closed Trial Search ID 573371
PDQ Open Trial Search ID 573371 (check for NCI PDQ open clinical trial info)
UMLS CUI C3467794

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C21H24NO8S.Na
code C71355
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Polo-like_kinase_1_Inhibitor_ON_01910_Na
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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