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Version: 17.06d (Release date: 2017-06-26)
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Ofloxacin (Code C712)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ofloxacin

Definition: A fluoroquinolone antibacterial antibiotic. Ofloxacin binds to and inhibits bacterial topoisomerase II (DNA gyrase) and topoisomerase IV, enzymes involved in DNA replication and repair, resulting in cell death in sensitive bacterial species. (NCI04)

NCI-GLOSS Definition: An antibiotic drug used to treat infection. It belongs to the family of drugs called quinolone antibiotics.

Label: Ofloxacin

NCI Thesaurus Code: C712 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0028902  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
9-Fluoro-2,3-Dihydro-3-Methyl-10-(4-Methyl-1-Piperazinyl)-7-Oxo-7H-Pyrido(1,2,3-de)(1,4)benzoxazine-6-Carboxylic Acid, DL-
DL-8280
Floxin
HOE 280
Ocuflox
OFLOXACIN
Ofloxacin
ofloxacin

External Source Codes: 
CAS Registry Number 83380-47-6 (see NLM ChemIDplus info)
CAS Registry Number 82419-36-1 (see NLM ChemIDplus info)
FDA UNII Code A4P49JAZ9H
ChEBI ID CHEBI:7731 (see ChEBI info)
NSC Code 727071 (see NCI DTP info)
PDQ Closed Trial Search ID 42865
PDQ Open Trial Search ID 42865 (check for NCI PDQ open clinical trial info)
UMLS CUI C0028902

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Various bacterial infections
Chemical_Formula C18H20FN3O4
code C712
Contributing_Source FDA
Legacy_Concept_Name Ofloxacin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C712

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