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Version: 17.06d (Release date: 2017-06-26)
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Natural IFN-alpha OPC-18 (Code C71159)

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Terms & Properties

Preferred Name: Natural IFN-alpha OPC-18

Definition: A proprietary preparation of natural human interferon alpha (IFN alpha) with potential immunomodulatory and antineoplastic activities. Natural human interferon alpha OPC-18 binds to cell-surface IFN alpha receptors (IFNARs), resulting in the transcription and translation of genes whose products mediate antiviral, antiproliferative, and immune-modulating effects. IFN alpha is a type I interferon produced by peripheral blood leukocytes or lymphoblastoid cells when exposed to live or inactivated virus, double-stranded RNA, or bacterial products and is the primary interferon produced by virus-induced leukocyte cultures. In addition to its pronounced antiviral activity, it activates NK cells.

Label: Natural IFN-alpha OPC-18

NCI Thesaurus Code: C71159 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376209  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Natural IFN-alpha OPC-18
nIFN-alpha OPC-18
OPC-18

External Source Codes: 
PDQ Closed Trial Search ID 571792
PDQ Open Trial Search ID 571792 (check for NCI PDQ open clinical trial info)
NCI META CUI CL376209

Other Properties:
     Name Value (qualifiers indented underneath)
code C71159
Legacy_Concept_Name Natural_IFN-alpha_OPC-18
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71159

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