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Version: 17.06d (Release date: 2017-06-26)
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Magnesium Valproate (Code C71156)

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Terms & Properties

Preferred Name: Magnesium Valproate

Definition: The magnesium salt of valproic acid (2-propylpentanoic acid) with antiepileptic and potential antineoplastic activities. Magnesium valproate dissociates in the gastrointestinal tract and is absorbed into the circulation as magnesium ions and valproic acid ions; valproic acid may inhibit histone deacetylases, inducing tumor cell differentiation, apoptosis, and growth arrest. In addition, valproic acid exerts an antiepileptic effect, likely by inhibiting enzymes that catabolize the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) catabolism and so increasing concentrations of GABA in the central nervous system (CNS). The presence of the magnesium in this agent may contribute to its anticonvulsant activity and sedative properties.

Label: Magnesium Valproate

NCI Thesaurus Code: C71156 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0524735  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Magnesium Dipropylacetate
Magnesium Valproate
Pentanoic acid, 2-propyl-, Magnesium Salt
Valproate Magnesium
VALPROATE MAGNESIUM

External Source Codes: 
CAS Registry Number 62959-43-7 (see NLM ChemIDplus info)
FDA UNII Code Q400352CM2
PDQ Closed Trial Search ID 573418
PDQ Open Trial Search ID 573418 (check for NCI PDQ open clinical trial info)
UMLS CUI C0524735

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula 2C8H15O2.Mg
code C71156
Contributing_Source FDA
Legacy_Concept_Name Magnesium_Valproate
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71156

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