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Version: 17.06d (Release date: 2017-06-26)
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High-Selenium Brassica juncea (Code C71154)

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Terms & Properties

Preferred Name: High-Selenium Brassica juncea

Definition: A formulation of the mustard plant Brassica juncea grown in a medium that has been enriched with the trace element selenium with potential chemopreventive and chemopotentiating activities. Brassica juncea hyperaccumulates trace elements in soil. Selenium amino acid species found in selenized Brassica juncea include methylselenomethionine (MeSeMet) and methylselenocysteine (MeSeCys); both may be incorporated into selenoproteins in vivo. Selenium functions as a cofactor for antioxidant enzymes such as glutathione peroxidases and thioredoxin reductase, which protect cells from the free radical damage. In addition, in vitro MeSeCys has been shown to potentiate the antitumor effects of the irinotecan metabolite SN-38, by inducing phosphorylation of checkpoint kinase 2 (chk2) at threonine 68, which results in poly(ADP-ribose) polymerase cleavage, caspase 3 activation, and DNA fragmentation.

NCI-GLOSS Definition: Brassica juncea that has been grown in high levels of selenium. Brassica juncea is a plant of the cabbage family that has been used in some cultures to treat certain medical problems, including arthritis, colds, stomach disorders, and tumors. The plant stores minerals, including selenium which may stop tumor cells from growing. High-selenium Brassica juncea is being studied in the treatment of cancer. Brassica juncea is also known as Indian mustard.

Display Name: High-Selenium Brassica juncea

Label: High-Selenium Brassica juncea

NCI Thesaurus Code: C71154 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL377692  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
High-Selenium Brassica juncea
high-selenium Brassica juncea

External Source Codes: 
PDQ Closed Trial Search ID 573427
PDQ Open Trial Search ID 573427 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C71154
Contributing_Source CTRP
Legacy_Concept_Name High-Selenium_Brassica_Juncea
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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