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Version: 17.06d (Release date: 2017-06-26)
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PVA Microporous Hydrospheres/Doxorubicin Hydrochloride (Code C71149)

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Terms & Properties

Preferred Name: PVA Microporous Hydrospheres/Doxorubicin Hydrochloride

Definition: An embolic material composed of microspheres of polyvinyl alcohol (PVA) polymers loaded with doxorubicin hydrochloride with antineoplastic activity. Doxorubicin hydrochloride-loaded microspheres may be used as a drug delivery vehicle during embolization of tumor vasculature. Doxorubicin intercalates DNA, interferes with catalytic activity of topoisomerase II, and causes DNA adducts and other DNA damage, resulting in tumor cell growth inhibition and apoptosis. When used in tumor vasculature embolization, this preparation may provide more tumor-specific treatment with doxorubicin compared to the systemic administration of doxorubicin, thereby reducing the systemic toxicity of doxorubicin.

Display Name: PVA Microporous Hydrospheres/Doxorubicin Hydrochloride

Label: PVA Microporous Hydrospheres/Doxorubicin Hydrochloride

NCI Thesaurus Code: C71149 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL376223  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HepaSphere Microspheres/Doxorubicin Hydrochloride
PVA Microporous Hydrospheres/Doxorubicin Hydrochloride
QuadraSphere Microspheres/Doxorubicin Hydrochloride

External Source Codes: 
PDQ Closed Trial Search ID 574045
PDQ Open Trial Search ID 574045 (check for NCI PDQ open clinical trial info)
NCI META CUI CL376223

Other Properties:
     Name Value (qualifiers indented underneath)
code C71149
Contributing_Source CTRP
Legacy_Concept_Name PVA_Microporous_Hydrospheres_Doxorubicin_Hydrochloride
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71149

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