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Version: 17.12d (Release date: 2017-12-26)
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Salirasib (Code C71146)

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Terms & Properties

Preferred Name: Salirasib

Definition: A salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast.

Display Name: Salirasib

Label: Salirasib

NCI Thesaurus Code: C71146 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0297001  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(((2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl)sulfanyl)benzoic Acid
S-Farnesylthiosalicylic Acid

External Source Codes: 
CAS Registry Number 162520-00-5 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 573226
PDQ Open Trial Search ID 573226 (check for NCI PDQ open clinical trial info)
UMLS CUI C0297001

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H30O2S
code C71146
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Salirasib
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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