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Version: 17.06d (Release date: 2017-06-26)
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Salirasib (Code C71146)

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Terms & Properties

Preferred Name: Salirasib

Definition: A salicylic acid derivative with potential antineoplastic activity. Salirasib dislodges all Ras isoforms from their membrane-anchoring sites, thereby preventing activation of RAS signaling cascades that mediated cell proliferation, differentiation, and senescence. RAS signaling is believed to be abnormally activated in one-third of human cancers, including cancers of the pancreas, colon, lung and breast.

Display Name: Salirasib

Label: Salirasib

NCI Thesaurus Code: C71146 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0297001  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(((2E,6E)-3,7,11-Trimethyl-2,6,10-dodecatrienyl)sulfanyl)benzoic Acid
S-Farnesylthiosalicylic Acid
Salirasib
SALIRASIB

External Source Codes: 
CAS Registry Number 162520-00-5 (see NLM ChemIDplus info)
FDA UNII Code MZH0OM550M
PDQ Closed Trial Search ID 573226
PDQ Open Trial Search ID 573226 (check for NCI PDQ open clinical trial info)
UMLS CUI C0297001

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H30O2S
code C71146
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Salirasib
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71146

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