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Version: 17.10e (Release date: 2017-10-30)
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Oral Microencapsulated Diindolylmethane (Code C71132)

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Terms & Properties

Preferred Name: Oral Microencapsulated Diindolylmethane

Definition: An orally bioavailable microencapsulated formulation of diindolylmethane, an indole phytonutrient found in cruciferous vegetables, with estrogen-modulating, antiandrogenic, and potential antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) modulates estrogen balance by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of beneficial 2-hydroxy estrogen metabolites. DIM also antagonizes androgen receptor activity, which may result in diminished cell proliferation and apoptosis in susceptible tumor cell populations. Pure DIM, which is relatively hydrophobic, is poorly absorbed after oral administration. This oral formulation, which consists of DIM, d-alpha-tocopheryl acid succinate, phosphatidylcholine, and silica microencapsulated in starch, significantly improves the gastrointestinal absorption of DIM.

Display Name: Oral Microencapsulated Diindolylmethane

Label: Oral Microencapsulated Diindolylmethane

NCI Thesaurus Code: C71132 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL377701  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BioResponse DIM
Oral Microencapsulated Diindolylmethane

External Source Codes: 
PDQ Closed Trial Search ID 577331
PDQ Open Trial Search ID 577331 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C71132
Contributing_Source CTRP
Legacy_Concept_Name Oral_Microencapsulated_Diindolylmethane
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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