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Version: 17.08d (Release date: 2017-08-28)
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[18F]-labeled Substance P Antagonist Receptor Quantifier (Code C71071)

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Terms & Properties

Preferred Name: [18F]-labeled Substance P Antagonist Receptor Quantifier

Definition: A radioconjugate consisting of the positron emitting radioisotope fluorine F 18 conjugated to the substance P antagonist receptor quantifier (SPA-RQ) used in radioimaging. [18F]-labeled substance P antagonist receptor quantifier is an antagonist of the neurokinin 1 (substance P) receptor (NK1R) and can function as a positron emission tomography (PET) imaging agent for detecting NK1R-expressing cells and tissues. NK1Rs are frequently expressed on the plasma membranes of tumor cells from glioblastoma and breast and pancreatic carcinomas.

NCI-GLOSS Definition: A radiolabeled substance being studied in PET imaging of the brain. It is also being studied as a way to find where cancer cells have spread in patients with pancreatic cancer. It binds to cell receptors for substance P, also known as neurokinin-1, which is found on nerve cells and on some types of cancer cells, such as pancreatic cancer cells. [18F]-labeled substance P antagonist receptor quantifier is a type of PET radioligand and a type of radiolabeled neurokinin-1 receptor antagonist.

Label: [18F]-labeled Substance P Antagonist Receptor Quantifier

NCI Thesaurus Code: C71071 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1872494  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[18F]-labeled substance P antagonist receptor quantifier
[18F]-labeled Substance P Antagonist Receptor Quantifier
[18F]SPA-RQ

External Source Codes: 
PDQ Closed Trial Search ID 573537
PDQ Open Trial Search ID 573537 (check for NCI PDQ open clinical trial info)
UMLS CUI C1872494

Other Properties:
     Name Value (qualifiers indented underneath)
code C71071
Legacy_Concept_Name _18F_SPA-RQ
Semantic_Type Chemical
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71071

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