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Version: 17.06d (Release date: 2017-06-26)
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Tamibarotene (Code C71025)

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Terms & Properties

Preferred Name: Tamibarotene

Definition: An orally active, synthetic retinoid, developed to overcome all-trans retinoic acid (ATRA) resistance, with potential antineoplastic activity. As a specific retinoic acid receptor (RAR) alpha/beta agonist, tamibarotene is approximately ten times more potent than ATRA in inducing cell differentiation and apoptosis in HL-60 (human promyelocytic leukemia) cell lines in vitro. Due to a lower affinity for cellular retinoic acid binding protein (CRABP), tamibarotene may show sustained plasma levels compared to ATRA. In addition, this agent may exhibit a lower toxicity profile than ATRA, in part, due to the lack of affinity for the RAR-gamma receptor, the major retinoic acid receptor in the dermal epithelium.

Display Name: Tamibarotene

Label: Tamibarotene

NCI Thesaurus Code: C71025 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1567753  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-((5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl)
Am-80
Am80
Benzoic Acid, 4-(((5,6,7,8-tetrahydro-5,5,8,8-Tetramethyl-2-naphthalenyl)amino)carbonyl)-
INNO-507
N-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)terephthalamic Acid
Retinobenzoic Acid
SY-1425
Tamibarotene
TAMIBAROTENE
TM-411
TOS-80T
Z-208

External Source Codes: 
CAS Registry Number 94497-51-5 (see NLM ChemIDplus info)
FDA UNII Code 08V52GZ3H9
ChEBI ID CHEBI:32181 (see ChEBI info)
NSC Code 608000 (see NCI DTP info)
PDQ Closed Trial Search ID 571791
PDQ Open Trial Search ID 571791 (check for NCI PDQ open clinical trial info)
UMLS CUI C1567753

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H25NO3
code C71025
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tamibarotene
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71025

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