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Version: 17.06d (Release date: 2017-06-26)
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Pidilizumab (Code C71014)

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Terms & Properties

Preferred Name: Pidilizumab

Definition: A humanized monoclonal antibody directed against human PD-1 (programmed cell death 1; PDCD1), with immunomodulating and antitumor activities. Pidilizumab blocks interaction between the receptor PD-1 with its ligands, PD-1 ligand 1 (PD-1L1) and PD-1 ligand 2 (PD-1L2), resulting in the attenuation of apoptotic processes in lymphocytes, primarily effector/memory T cells, and the augmentation of the anti-tumor activities of NK cells. PD-1 is an inhibitory receptor belonging to the B7-receptor family that is expressed on lymphocytes and myeloid cells; its ligands, PD-1L1 and PD-1L2, are expressed not only by hematopoietic cells but also by cells in non-lymphoid tissues.

Display Name: Pidilizumab

Label: Pidilizumab

NCI Thesaurus Code: C71014 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346821  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CT-011
CT 011
Immunoglobulin G1, Anti-(Human Programmed Cell Death 1); Humanized Mouse Monoclonal CT-011 Gamma1 Heavy Chain (220-213')-disulfide with Humanized Mouse Monoclonal CT-011 Kappa Light Chain Dimer (226-226'':229-229'')-bisdisulfide, Glycosylated (CT-011 is Expressed in NSO Cells)
MDV9300
Pidilizumab
PIDILIZUMAB

External Source Codes: 
CAS Registry Number 1036730-42-3 (see NLM ChemIDplus info)
FDA UNII Code B932PAQ1BQ
PDQ Closed Trial Search ID 573227
PDQ Open Trial Search ID 573227 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346821

Other Properties:
     Name Value (qualifiers indented underneath)
code C71014
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-PD-1_Monoclonal_Antibody_CT-011
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71014

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