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Version: 17.06d (Release date: 2017-06-26)
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Pidilizumab (Code C71014)

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Terms & Properties

Preferred Name: Pidilizumab

Definition: A humanized monoclonal antibody directed against human PD-1 (programmed cell death 1; PDCD1), with immunomodulating and antitumor activities. Pidilizumab blocks interaction between the receptor PD-1 with its ligands, PD-1 ligand 1 (PD-1L1) and PD-1 ligand 2 (PD-1L2), resulting in the attenuation of apoptotic processes in lymphocytes, primarily effector/memory T cells, and the augmentation of the anti-tumor activities of NK cells. PD-1 is an inhibitory receptor belonging to the B7-receptor family that is expressed on lymphocytes and myeloid cells; its ligands, PD-1L1 and PD-1L2, are expressed not only by hematopoietic cells but also by cells in non-lymphoid tissues.

Display Name: Pidilizumab

Label: Pidilizumab

NCI Thesaurus Code: C71014 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346821  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CT 011
Immunoglobulin G1, Anti-(Human Programmed Cell Death 1); Humanized Mouse Monoclonal CT-011 Gamma1 Heavy Chain (220-213')-disulfide with Humanized Mouse Monoclonal CT-011 Kappa Light Chain Dimer (226-226'':229-229'')-bisdisulfide, Glycosylated (CT-011 is Expressed in NSO Cells)

External Source Codes: 
CAS Registry Number 1036730-42-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 573227
PDQ Open Trial Search ID 573227 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346821

Other Properties:
     Name Value (qualifiers indented underneath)
code C71014
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-PD-1_Monoclonal_Antibody_CT-011
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  


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