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Version: 17.12d (Release date: 2017-12-26)
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Carlumab (Code C71010)

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Terms & Properties

Preferred Name: Carlumab

Definition: A human IgG1 kappa monoclonal antibody directed against human CC chemokine ligand 2 (CCL2) with potential antineoplastic activity. Carlumab binds to and inhibits CLL2, which may result in inhibition of angiogenesis and, so, tumor cell proliferation. Endothelium-derived CLL2 (monocyte chemoattractant protein; MCP1) is a member of the beta-chemokine family, can stimulate monocyte/macrophage migration and smooth muscle cell (SMC) proliferation, and plays a role in angiogenesis and tumor cell migration; CCL2 induction of angiogenesis may involve the upregulation of hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression which, in turn, induces vascular endothelial growth factor-A (VEGF-A) gene expression.

Display Name: Carlumab

Label: Carlumab

NCI Thesaurus Code: C71010 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3537194  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-human Small-inducible Cytokine A2 Monoclonal Antibody CNTO 888
CNTO 888
Immunoglobulin G1, anti-(human monocyte chemoattractant protein-1) (human monoclonal CNTO888 gamma 1-chain), disulfide with human monoclonal CNTO888 kappa-chain, dimer

External Source Codes: 
CAS Registry Number 915404-94-3 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 573742
PDQ Open Trial Search ID 573742 (check for NCI PDQ open clinical trial info)
UMLS CUI C3537194

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C6442H9966N1706O2018S40
code C71010
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-CCL2_Human_Monoclonal_Antibody_CNTO_888
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  


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