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Version: 16.11d (Release date: 2016-11-28)
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Carlumab (Code C71010)

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Terms & Properties

Preferred Name: Carlumab

Definition: A human IgG1 kappa monoclonal antibody directed against human CC chemokine ligand 2 (CCL2) with potential antineoplastic activity. Carlumab binds to and inhibits CLL2, which may result in inhibition of angiogenesis and, so, tumor cell proliferation. Endothelium-derived CLL2 (monocyte chemoattractant protein; MCP1) is a member of the beta-chemokine family, can stimulate monocyte/macrophage migration and smooth muscle cell (SMC) proliferation, and plays a role in angiogenesis and tumor cell migration; CCL2 induction of angiogenesis may involve the upregulation of hypoxia-inducible factor 1 alpha (HIF-1 alpha) gene expression which, in turn, induces vascular endothelial growth factor-A (VEGF-A) gene expression.

Display Name: Carlumab

Label: Carlumab

NCI Thesaurus Code: C71010 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3537194  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-human Small-inducible Cytokine A2 Monoclonal Antibody CNTO 888
Carlumab
CARLUMAB
CNTO 888
Immunoglobulin G1, anti-(human monocyte chemoattractant protein-1) (human monoclonal CNTO888 gamma 1-chain), disulfide with human monoclonal CNTO888 kappa-chain, dimer

External Source Codes: 
CAS Registry Number 915404-94-3 (see NLM ChemIDplus info)
FDA UNII Code 6TC1BB2EV9
PDQ Closed Trial Search ID 573742
PDQ Open Trial Search ID 573742 (check for NCI PDQ open clinical trial info)
UMLS CUI C3537194

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C6442H9966N1706O2018S40
code C71010
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Anti-CCL2_Human_Monoclonal_Antibody_CNTO_888
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C71010

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