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Version: 17.06d (Release date: 2017-06-26)
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Linsitinib (Code C70982)

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Terms & Properties

Preferred Name: Linsitinib

Definition: An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It blocks a protein called IGF-1R, which is found at high levels in some types of tumors. IGF-1R is needed for cell growth and blocking it may cause tumor cells to die. IGF-1R inhibitor OSI-906 is a type of IGF-1R inhibitor.

Display Name: Linsitinib

Label: Linsitinib

NCI Thesaurus Code: C70982 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346449  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
cis-3-(8-Amino-1-(2-Phenylquinolin-7-yl)Imidazo(1,5-A)Pyrazin-3-yl)-1-Methylcyclobutanol
Cyclobutanol, 3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl, cis-
IGF-1R inhibitor OSI-906
Linsitinib
LINSITINIB
OSI-906
OSI-906AA

External Source Codes: 
CAS Registry Number 867160-71-2 (see NLM ChemIDplus info)
FDA UNII Code 15A52GPT8T
PDQ Closed Trial Search ID 566191
PDQ Open Trial Search ID 566191 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346449

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H23N5O
code C70982
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name IGF-1R_Inhibitor_OSI-906
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C70982

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