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Version: 17.06d (Release date: 2017-06-26)
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Linsitinib (Code C70982)

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Terms & Properties

Preferred Name: Linsitinib

Definition: An orally bioavailable small molecule inhibitor of the insulin-like growth factor 1 receptor (IGF-1R) with potential antineoplastic activity. Linsitinib selectively inhibits IGF-1R, which may result in the inhibition of tumor cell proliferation and the induction of tumor cell apoptosis. Overexpressed in a variety of human cancers, IGF-1R stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. It blocks a protein called IGF-1R, which is found at high levels in some types of tumors. IGF-1R is needed for cell growth and blocking it may cause tumor cells to die. IGF-1R inhibitor OSI-906 is a type of IGF-1R inhibitor.

Display Name: Linsitinib

Label: Linsitinib

NCI Thesaurus Code: C70982 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2346449  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cyclobutanol, 3-[8-amino-1-(2-phenyl-7-quinolinyl)imidazo[1,5-a]pyrazin-3-yl]-1-methyl, cis-
IGF-1R inhibitor OSI-906

External Source Codes: 
CAS Registry Number 867160-71-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 566191
PDQ Open Trial Search ID 566191 (check for NCI PDQ open clinical trial info)
UMLS CUI C2346449

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C26H23N5O
code C70982
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name IGF-1R_Inhibitor_OSI-906
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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