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Version: 17.06d (Release date: 2017-06-26)
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Dornase Alfa Inhalation Solution (Code C70980)

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Terms & Properties

Preferred Name: Dornase Alfa Inhalation Solution

Definition: A highly purified solution of recombinant human deoxyribonuclease I (rhDNAse) with selective DNA cleaving activity. Administrated through inhalation of the nebulized solution, dornase alpha catalyzes DNA degradation in viscous airway secretions, which may render airway secretions less viscous, thus promoting the clearing of airway mucous plugging and improvement in pulmonary function.

NCI-GLOSS Definition: A drug given in an aerosol mist to decrease the thickness of mucus in the lungs of patients with cystic fibrosis. It is also being studied as a treatment to reduce the thickness of saliva in patients being treated for head and neck cancer. Dornase alfa inhalation solution contains an enzyme that breaks the DNA in mucus into small pieces and makes the mucus thinner.

Display Name: Dornase Alfa Inhalation Solution

Label: Dornase Alfa Inhalation Solution

NCI Thesaurus Code: C70980 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0251564  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Dornase Alfa Inhalation Solution
dornase alfa inhalation solution
Pulmozyme
Recombinant Human Deoxyribonuclease I Inhalation Solution
rhDNAse Inhalation Solution

External Source Codes: 
PDQ Closed Trial Search ID 570123
PDQ Open Trial Search ID 570123 (check for NCI PDQ open clinical trial info)
UMLS CUI C0251564

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Cystic Fibrosis
code C70980
Contributing_Source CTRP
Legacy_Concept_Name Dornase_Alfa_Inhalation_Solution
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C70980

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