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Version: 17.06d (Release date: 2017-06-26)
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HIF-1alpha Inhibitor PX-478 (Code C70953)

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Terms & Properties

Preferred Name: HIF-1alpha Inhibitor PX-478

Definition: An orally active small molecule with potential antineoplastic activity. Although its mechanism of action has yet to be fully elucidated, HIF1-alpha inhibitor PX-478 appears to inhibit hypoxia-inducible factor 1-alpha (HIF1A) expression, which may result in decreased expression of HIF1A downstream target genes important to tumor growth and survival, a reduction in tumor cell proliferation, and the induction of tumor cell apoptosis. The inhibitory effect of this agent is independent of the tumor suppressor genes VHL and p53 and may be related to derangements in glucose uptake and metabolism due to inhibition of glucose transporter-1 (Glut-1).

Display Name: HIF-1alpha Inhibitor PX-478

Label: HIF-1alpha Inhibitor PX-478

NCI Thesaurus Code: C70953 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1528551  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(S)-4-(2-Amino-2-carboxyethyl)-N,N-bis(2-chloroethyl)aniline Oxide Dihydrochloride
HIF-1alpha Inhibitor PX-478
Hypoxia Inducible Factor 1-Alpha PX-478
L-Phenylalanine, 4-[Bis(2-chloroethyl)oxidoamino]-, Dihydrochloride; L-Phenylalanine, 4-[Bis(2-chloroethyl)oxidoamino]-, Hydrochloride (1:2)
PX-478

External Source Codes: 
CAS Registry Number 685898-44-6 (see NLM ChemIDplus info)
FDA UNII Code T23U22X160
PDQ Closed Trial Search ID 570895
PDQ Open Trial Search ID 570895 (check for NCI PDQ open clinical trial info)
UMLS CUI C1528551

Other Properties:
     Name Value (qualifiers indented underneath)
code C70953
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Hypoxia_Inducible_Factor_1-Alpha_PX-478
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C70953

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